ACRC Researchers Find New Link to Hypertension

Making the Rounds

One of the benefits of working in the Abboud Cardiovascular Research Center (ACRC) is that researchers have ready access to collaborators. A publication earlier this year in the Journal of Allergy and Clinical Immunology shows the results of one such collaboration within the ACRC. The article both identifies a specific immune cell cytokine in hypertensive rats that impairs the normal relaxation of aortic vessels and a means of preventing it. Identifying this mechanism presents a potential therapeutic target in the treatment of Singh_MV_Graphic Abstract R2-JACIhuman hypertension.

Dr. François Abboud and Dr. Madhu Singh have been studying the link between the immune system and high blood pressure. In fact, Dr. Singh points out, there is “evidence that hypertension may be considered as an autoimmune disease.” Though what happens at the cellular and molecular levels is less understood and thus the focus of Dr. Abboud and Dr. Singh’s work with spontaneously hypertensive rats (SHR)…

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