Two Publications Identify “Longevity” Enzyme Interactions

Making the Rounds

For the last couple decades, a particular enzyme has been the focus of intense study. Sirtuin1 was found to be a key protein affecting the longevity of some organisms such as yeast. Decrease in caloric intake, which could lengthen cell life, became ineffective in the absence of sirtuin1. At the time of its discovery it was hailed as a potential “fountain of youth.”

Although its promise as the fountain of youth remains unfulfilled, the discovery of sirtuin1 has still opened plenty of other interesting avenues for research. Years of research into this enzyme and its reach have resulted in two recent, high-profile publications from the University of Iowa. The first, appearing in the January issue of PNAS, identifies a connection between sirtuin 1 and p66Shc, a protein that promotes oxidative stress and has been shown to degrade or limit the life span of some mammals. For example, by deleting…

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